SST tube
1.0 mL serum
1.0 mL serum
Collect specimen in SST tube. Centrifuge, aliquot serum into a plastic vial and freeze.
Collect specimen in SST tube. Centrifuge, aliquot serum into a plastic vial and freeze.
Monday, Thursday
8 hours
Indirect Fluorescent Antibody (IFA), human neutrophil substrate
Negative. Two common patterns have been recognized. One pattern is a finely granular staining of cytoplasmic granules; C-Neutrophil Cytoplasmic autoantibodies (C-NCA). The most common antibody that accounts for this pattern is anti-proteinase 3. C-NCA has been described in patients with Granulomatosis with Polyangiitis (GPA), polyarteritis nodosa and some types of crescentic glomerulonephritis. The second pattern shows a strong perinuclear fluorescence but little or no staining in the cytoplasm. This pattern has been attributed to anti-myeloperoxidase. The perinuclear NCA pattern (P-NCA) is associated with vasculitis but is not as specific for GPA as the cytoplasmic (C-NCA) pattern.
Neutrophil cytoplasmic antibody testing is useful in the evaluation of patients with vasculitis. GPA is a disease which results in a necrotizing granulomatous vasculitis in the upper and lower respiratory tract as well as in the kidney. Autoantibodies against neutrophil cytoplasmic antigens have been found in these patients. These antibodies have also been observed in microscopic polyarteritis, and other types of vasculitis.
If the screen is positive, a titer will be performed at an additional charge. The laboratory may also request anti-myeloperoxidase and/or anti-proteinase 3 to help in his or her interpretation. By ordering this test the clinician acknowledges that additional reflex testing will be performed and billed at a separate additional charge if indicated. This test is not available without interpretation.
17353-4 NCAB, 14277-8 NCABT, 46267-1 PR3N, 63310-7 PR3I, 46266-3 MYLON, 29643-4 MYLOI
86036
KA041
86037, 86037-26 NCABT, 83516 MYELO, 83516 PR3
KA042 NCABT, 21594 MYELO, 21595 PR3
Red top tube.